Video: Autonomic Pharmacology | Adrenergic Antagonists

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In this high-yield pharmacology lecture, Professor Zach Murphy breaks down the essential concepts behind Adrenergic Antagonists, focusing on their mechanisms of action, receptor selectivity, clinical indications, and side effect profiles. This lecture will give you a structured understanding of how these drugs inhibit sympathetic nervous system activity and where they are used in clinical practice.

We begin with a quick review of adrenergic receptor subtypes (α1, α2, β1, β2, β3) and their physiologic roles. From there, we categorize adrenergic antagonists based on their receptor specificity, including:

• Alpha blockers: Prazosin, Doxazosin, Phenoxybenzamine, Phentolamine

• Beta blockers: Propranolol, Metoprolol, Atenolol, Labetalol, Carvedilol, Esmolol, Timolol

• Mixed alpha and beta blockers: Labetalol and Carvedilol

• Selective vs non-selective agents

Each agent is discussed in detail, highlighting:

• Mechanism of action: Competitive antagonism at adrenergic receptors

• Receptor selectivity: Impact on vascular tone, cardiac output, and bronchodilation

• Clinical uses: Hypertension, angina, heart failure, arrhythmias, pheochromocytoma, glaucoma, BPH

• Adverse effects: Bradycardia, bronchospasm, orthostatic hypotension, fatigue, rebound hypertension

Enjoy the lecture and support us below!

Table of Contents:

0:00 Lab

0:07 Adrenergic Antagonists Introduction

1:07 Adrenergic Neurons and Receptors

12:20 Adrenergic Target Organ Effects

24:47 Alpha 1 Antagonists

33:28 Alpha 1 + 2 Antagonists

49:48 Beta Antagonists

1:13:08 Beta 1 + 2 Antagonists

1:28:06 Beta + Alpha Blockers

1:40:30 Beta Blocker Overdose

1:47:30 Adrenergic Antagonists Practice Problems

1:58:54 Comment, Like, SUBSCRIBE!

Pharmacology Source:

Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition.

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